Internal Medicine, Cell Biology Washington University in St. Louis St. Louis, MO


Research Interests:

The goal of our work is to understand the pathologic processes of lung disease to identify strategies for reversal. This work encompasses airway diseases such as asthma, chronic obstructive pulmonary disease, and bronchiectasis, including genetic forms of these disorders. Our approach has been to understand the function of airway progenitor cells, regulatory mechanisms of airway epithelial cell differentiation during health and pathologic states that lead to abnormal ciliated and goblet cell function. Another major focus involves motile ciliated cells, mechanisms of cilia assembly, and how these are related to the genetic disease primary ciliary dyskinesia. We are also using similar approaches to identify acquired defects of cilia in common airway diseases. For these studies we culture and analyze of human airway epithelial cells from clinical samples.

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University of Michigan, M.D.
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